S-آدنوزیل متیونین

دانستن اینکه یک مکمل مؤثر است اهمیت زیادی دارد، اما به همان اندازه مهم است که بدانیم آیا مصرف آن ایمن است یا خیر. بخش اطلاعات ایمنی آقای بدنساز، اطلاعاتی مبتنی بر شواهد درباره مهم‌ترین جنبه‌های ایمنی، از جمله عوارض جانبی، تداخلات و احتیاط‌های لازم برای گروه‌های خاص یا افراد مبتلا به برخی بیماری‌ها ارائه می‌دهد. اطلاعات مربوط به ایمنی مکمل‌ها همیشه به‌راحتی در دسترس نیست و تفسیر آن نیز می‌تواند دشوار باشد. به همین دلیل، تیم پژوهشگران آقای بدنساز، پژوهش‌های موجود را با دقت بررسی، تحلیل و جمع‌بندی کرده‌اند تا به شما و مراجعانتان کمک کنند تصمیم‌هایی آگاهانه‌تر و ایمن‌تر بگیرید.

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خلاصه نکات ایمنی

S-adenosylmethionine most commonly causes gastrointestinal side effects, including constipation, abdominal pain, and nausea. Caution is warranted in pregnancy and lactation. Currently, data supporting its use is only available in the third trimester. S-adenosylmethionine can increase levels of serotonin and should be used cautiously while taking other serotonergic drugs (e.g., drugs commonly used for depression). S-adenosylmethionine should be avoided in people with bipolar disorder. A subject in one study developed a manic episode with suicidal ideation after two weeks of S-adenosylmethionine at a dose of ۱,۶۰۰ mg daily.

عوارض جانبی

S-adenosylmethionine seems to be generally well-tolerated, with the most common adverse effects being gastrointestinal complaints. In many cases, adverse effects have been reported at a similar rate to placebo.

عارضه	جزئیات
Constipation	Route: Oral
Abdominal pain	Route: Oral
Headache	Route: Oral
Nausea	Route: Oral
Diarrhea	Route: Oral
Flatulence	Route: Oral
Anxiety	Route: Oral
Decreased appetite	Route: Oral
Hypomania	Route: Oral

تداخل‌ها

عامل	توضیحات تداخل	سطح شواهد	شدت
Agent Effect	Level of Evidence Serotonergic drugs Combining S-adenosylmethionine with drugs that increase serotonin availability or action, such as serotonin reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs) , or tricyclic antidepressants (TCAs), may increase the risk of serotonin syndrome. Despite this risk, some studies showed that S-adenosylmethionine may provide additional therapeutic benefit when combined with other serotonergic drugs for the treatment of depression. Possible Severe Antipsychotics First-generation antipsychotics (e.g., haloperidol, droperidol, fluphenazine) work primarily by inhibiting dopamine receptors. S-adenosylmethionine may increase the metabolism of dopamine, potentially enhancing this antagonistic effect. In theory, this may increase the risk of side effects due to reduced dopamine action, such as extrapyramidal symptoms (e.g., involuntary movements of the body), neuroleptic malignant syndrome, and sexual dysfunction.	Theoretical	Unknown
Levodopa	S-adenyosylmethionine may act as a methyl donor and contribute to the breakdown of levodopa in the body. This may reduce levodopa’s efficacy when used in people with Parkinson’s disease.	Theoretical	Unknown
Linezolid	Over extended treatment durations (۱۴ days or greater), linezolid’s effect as a weak monoamine oxidase inhibitor may increase serotonin levels. When combined with S-adenosylmethionine, this effect may be exaggerated and contribute to the development of serotonin syndrome.	Theoretical	Unknown
Serotonergic supplements	Combining S-adenosylmethionine with supplements that increase serotonin availability or action may increase the risk of serotonin syndrome. Despite this risk, some studies showed that S-adenosylmethionine may provide additional therapeutic benefit when combined with other serotonergic drugs for the treatment of depression.	Theoretical	Unknown

منابع